Endocrine Abstracts

Background: Affected patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) are often insufficiently informed about disease-specific aspects of reproduction. Reasons for lower fertility rates in female patients with CAH are hormonal dysregulations, anatomical changes resulting from virilized genital surgeries and psychosocial and psychosexual factors. Fecundity, however, is comparable to the normal population. Male patients with CAH also ha...

Background: International Diabetes Federation (IDF), in collaboration with the Diabetes and Ramadan (DAR) International Alliance proposed in 2021, IDF-DAR Practical Guidelines with a score that allows certain patients even on insulin to fast which requires regular and appropriate blood glucose monitoring.Aim: Develop a special Ramadan blood glucose self-monitoring table in order to limit the risk of acute compilations during this month.<p class="abst...

Introduction: The gut hormone peptide YY 3-36 (PYY3-36) is secreted postprandially from intestinal L-cells to signal satiety. Peripheral administration of PYY3-36 suppresses food intake in rodents and humans. PYY3-36-based drugs are therefore promising anti-obesity treatments. It has been proposed that circulating PYY3-36 supresses appetite via the Y2 receptor (Y2R) in the hypothalamic arcuate nucleus (ARC). The vagus nerve, the majo...

Introduction: Due to improved cancer survival rates, a rising number of CNS cancer survivors face late effects of therapy, such as hormone deficiencies. During adolesecence and young adulthood, specialised transition services are needed to cater for young peoples complex health needs and general needs, such as achieving independence. This study therefore audited a Teenage & Young Adult (TYA) neuro-oncology late effects clinic to identify areas of good practice and areas fo...

Metabolic syndrome and its hepatic manifestation, non-alcoholic fatty liver disease (NAFLD), are increasing in prevalence. Steroid hormones are established regulators of metabolic phenotype. 5β-reductase (AKR1D1) is highly expressed in human liver, inactivating steroid hormones, including glucocorticoids and androgens. The human AKR1D1 gene contains 9 exons; six splice variants have been identified and three lead to functional protein isoforms (AKR1D1-001, -0...

Introduction: Hypertriglyceridemia is an established complication associated with some parenterally fed patients. In healthy individual, lipid particles are hydrolyzed to release fatty acids via the action of lipoprotien lipase (LPL) which used eventually for energy or stored in adipose tissue. In stressed patient, the activity of LPL is decreased. We present a 16-year-old girl, who is a known case of acute myeloid leukemia on chemotherapy, was admitted to the hospital with se...

Aim: To investigate the clinical efficacy of the treatment of patients with neuro-ishemic diabetic foot ulcers (DF) by using sorption-antimicrobial nanocomposition based on silica sorbents.Methods: Hydrophobic-hydrophilic sorption-antibacterial nanocomposition, offered for the treatment of ulcers and wounds, contains sorbents (nano-disperse silicon dioxide, polymethylsiloxane) and antibacterial components (decamethoxin, metronidazole). In this study 78 p...

Background and aims: Comparative animal study of efficacy of intermittent short courses administration of lyophilized single-, three- and alive multistrain probiotic on insulin resistance in rats with experimental obesity.Methods: We included 70 rats divided into 7 groups (n=10 in each). Rats of group I were intact. Newborn rats of groups II-VII were injected with monosodium glutamate (MSG) (4 mg/g). Rats of group II (MSG-obesity group) were unt...

According to state statistics service, Russia’s population in 2018 is more than 146.8 mil people. The total prevalence of acromegaly may range between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates vary between 0.2 and 1.1 cases per 100,000 people (Lavrentaki A, et al. 2016). The epidemiological data for acromegaly in Russian population is lacking. The Russian hypothalamic and pituitary tumors registry was founded in 2004 and for 2018 it con...

Introduction: Proteinuria is a condition in which urine contains an abnormal amount of protein. Proteinuria is a sign of chronic kidney disease (CKD), which can result from diabetes, high blood pressure and other diseases that cause inflammation in the kidneys. If CKD progresses, it can lead to end-stage renal disease, when the kidneys fail completely.Case presentation: Sixty-three years old female patient attended our clinic as her glycaemia was poor co...